J Vasc Bras 2020 Jul 6;19:e20190150. doi: 10.1590/1677-5449.190150. Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease Felipe Esdras Lucas Cardoso 1, Leandro da Cruz Melgaço Dos Santos 1, Adirlene Pontes de Oliveira Tenório 1, Matheus Rodrigues Lopes 1, Romero Henrique de Almeida Barbosa 1 Abstract Vitamin D (1,25-dihydroxycolecalciferol) is a prohormone that has attracted the interest of researchers since studies have shown that its effects are not restricted to bone metabolism. Thus, the present review summarizes the most recent findings and discusses the usefulness of prescribing vitamin D and its analogues for treatment and prevention of cardiovascular disorders and endothelial dysfunction. The paper constitutes a narrative review of the literature, selecting articles published from 2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial effects on endothelial function, but these results are controversial, since research with larger samples and of longer duration found no reduction in morbidity and mortality or cardiovascular risk factors after use of these substances. Given the current state of the art, there is no clear scientific basis for supplementation with vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular disease. Keywords: cardiovascular diseases; dietary supplements; endothelium; vitamin D.
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