Significance and Mechanistic Relevance of SIRT6-Mediated

Endothelial Dysfunction in Cardiovascular Disease Progression

Significance and Mechanistic Relevance of SIRT6-Mediated Endothelial Dysfunction in Cardiovascular Disease Progression Figure.​Schematic representation of endothelial dysfunction and its influence on function and mechanisms of endothelial cells (EC). Highlighted in green is the conclusion according to Guo et al.5Endothelial dysfunction impairs proteostasis, eNOS (endothelial NO synthase) functions, and angiogenesis and promotes senescence, vascular inflammation, and remodeling of ECs. Several mechanisms including regulation of Nkx3.2-GATA5 signaling, eNOS uncoupling, endothelium to mesenchymal transition (EndoMT), impaired proteostasis, and EDHF (endothelium-dependent hyperpolarization factor) have been uncovered to emphasize the importance of endothelial dysfunction and its causative role in cardiovascular diseases. H3K9ac indicates lysine 56 of histone H3; and SIRT6, sirtuin6. Access Ful-text