risk factors in a healthy female population
Pascal Vuilleumier 1, Dumeng Decosterd, Marc Maillard, Michel Burnier, Daniel Hayoz
Affiliations expand
PMID: 12195115
DOI: 10.1097/00004872-200209000-00018
Abstract Objective: To examine whether forearm postischemic skin reactive hyperemia (SRH) measured by laser Doppler flowmetry (LDF) can be used to explore microvascular function and whether LDF response is related to cardiovascular (CV) risk in a population study. Methods: SRH of the forearm defined as the percentage increase in cutaneous blood flow from resting conditions to peak dilation following a 2 min upper arm occlusion and CV risk factors were measured prospectively in 862 healthy females screened for cardiovascular risk factors in the context of a campaign designed to promote the 'control' of CV risk factors in women. Results: The Framingham risk score was constructed from age, sex, systolic and diastolic blood pressure, diabetes, total and high-density lipoprotein-cholesterol and left ventricular hypertrophy (Cornell product. The Cornell product for women was calculated as the QRS duration (ms) (R aVL + S V3 + 6 mV)). Although the score was low in this female population (CV event risk at 10 years 7.89) (95% confidence interval, 7.49-8.30) aged 40 to 75 years, we observed an inverse correlation between SRH of the forearm and the CV risk score ( P<0.001). Hormonal replacement therapy (39.4% of the study population was on hormone replacement therapy) had no significant influence on forearm postischemic SRH in this particular population. Conclusions: This study shows that in a very low CV risk female population, a significant correlation can be observed between the weight of CV risks and the impairment of postischemic forearm SRH. Thus, skin laser Doppler flowmetry may represent a valuable, simple and non-invasive tool to assess and monitor microvascular function in future prospective observational and interventional studies.
Comment in
Steps ahead in the non-invasive testing of vascular function.Hornig B, Drexler H.J Hypertens. 2002 Sep;20(9):1697-8. doi: 10.1097/00004872-200209000-00005.PMID: 12195102 No abstract available.
Similar articles
Reproducibility and methodological issues of skin post-occlusive and thermal hyperemia assessed by single-point laser Doppler flowmetry.Roustit M, Blaise S, Millet C, Cracowski JL.Microvasc Res. 2010 Mar;79(2):102-8. doi: 10.1016/j.mvr.2010.01.001. Epub 2010 Jan 11.PMID: 20064535
Dependence of human forearm skin postocclusive reactive hyperemia on occlusion time.Tee GB, Rasool AH, Halim AS, Rahman AR.J Pharmacol Toxicol Methods. 2004 Jul-Aug;50(1):73-8. doi: 10.1016/j.vascn.2004.02.002.PMID: 15233971 Clinical Trial.
Reproducibility of different laser Doppler fluximetry parameters of postocclusive reactive hyperemia in human forearm skin.Yvonne-Tee GB, Rasool AH, Halim AS, Rahman AR.J Pharmacol Toxicol Methods. 2005 Sep-Oct;52(2):286-92. doi: 10.1016/j.vascn.2004.11.003. Epub 2005 Jan 11.PMID: 16125628
Comparison of laser speckle contrast imaging with laser Doppler for assessing microvascular function.Tew GA, Klonizakis M, Crank H, Briers JD, Hodges GJ.Microvasc Res. 2011 Nov;82(3):326-32. doi: 10.1016/j.mvr.2011.07.007. Epub 2011 Jul 22.PMID: 21803051
The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis.Fuchs D, Dupon PP, Schaap LA, Draijer R.Cardiovasc Diabetol. 2017 Jan 19;16(1):11. doi: 10.1186/s12933-016-0487-1.PMID: 28103890. Review.
Comentários